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Criteria Specification (CSpec) Editor is intended for the management and approval of the Criteria Specifications that are used in the classification of variants by the ClinGen Variant Curation Expert Panels and the Sequence Variant Interpretation Working Group respectively.

For general information about the ClinGen Expert Panels and Variant Curation please visit: ClinGen Clinical Domain Working Groups.

Should you encounter any issues regarding the data displayed, lack of functionality or other problems, please let us know by contacting us via email.

Version History

  • (2024-06-24)
    Version 1.0.13
    • Added validation for disease entity and mode of inheritance.
    • Added validation for gene transcripts
  • (2024-01-18)
    Version 1.0.12
    • Added support for multiple transcripts. Following features - create new specifications and edit scope of a specfication, now supports selecting multiple transcripts.
    • Fixed bug where release notes fields were presented during review and submission of the first version of a specification.
    • Fixed download PDF feature.
  • (2023-12-14)
    Version 1.0.11
    • Added new menu item My Roles which summarises the roles and VCEP affiliations.
    • Upgraded support to handle users with multiple roles.
    • Incremented Data Exchange message schema for the ruleset queue to 1.1.0.
  • (2023-11-17)
    Version 1.0.10
    • Approved For Release state for a specification document is to remain uneditable for all the VCEP coordinators; this feature was fixed.
    • Fixed bug to record accurate event names for the cspec-vci data stream.
    • Fixed bug for the versions page to accurately prompt the login form when accessed without propert authentication.
  • (2023-10-30)
    Version 1.0.9
    • Added new support to associate multiple modes of inheritance to a disease entity.
  • (2023-09-21)
    Version 1.0.8
    • Added new support for tracking history of all the CSpec approval stages.
  • (2023-08-09)
    Version 1.0.7
    • Fixed bug where patch versions were added incorrectly by the users. Entry of patch version is blocked.
    • Added backend support to use updated LDH libraries.
    • Automated versioning uses the CSpec APIs.
  • (2023-07-20)
    Version 1.0.6
    • Added new feature support to edit scope. VCEPs can now edit the scope of a criteria specification document prior to Step 2 and 3 submissions.
    • Added expandable and collapsible scope info at the main document view page.
    • Support for adding general comments to a specification is available with this version.
    • Support for the SVI Review Committee members to move a document to another stage once submitted is also released with this version.
  • (2023-04-28)
    Version 1.0.5
    • Added support to place reserved filenames for PDF downloads.
    • Criteria code specific supporting documents and links for the SVI guidance are now available for the VCEP coordinators.
  • (2023-02-15)
    Version 1.0.4
    • Added support to filter files as publicly or privately accessible before the release of a criteria specification document.
    • Approver summary now available for both VCEP coordinators and SVI Review approvers.
    • Download the document in PDF format.
    • Added support to highlight the comment tools for which the comments are added by the SVI Review approver.
  • (2022-11-09)
    Version 1.0.3
    • Added support to overwrite version after submission and withdrawals.
    • Instructions field for a criteria code has now full markdown support.
  • (2022-11-04)
    Version 1.0.2
    • Fixed context specific file access in the Editor.
    • Fixed image rendering issues
  • (2022-10-06)
    Version 1.0.1
    • Added support for automated email notifications when a document is submitted, withdrawn, reviewed or approved.
    • Added support for optional comments field during approval and withdrawals.
    • Added support for creating gene-disease-vcep specific documents rather than gene-vcep specific documents
  • (2022-08-24)
    Version 1.0.0
    • Added features to track SVI approval stages.
    • Updated specification document structure to include the SVI approval stages.
    • Synchronised CSpec Regsitry data and UI with CSpec Editor version 1.0.0.
    • Upgraded JSON API to include references, rules for combining criteria code, file attachments and extensive markdown support for the specification text.
    • Added user management system with role-based access to the Editor for the VCEP members.
    • Added support to create new specification document, reopen a previously approved specification to make updates, submit documents for approval and release approved specifications to the CSpec Registry
    • Added support for versioning all SVI approved specifications.